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News: 2011

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Wellcome Trust announces 2010/11 annual results The Wellcome Trust today publishes its 'Annual Report and Financial Statements' for the year from 1 October 2010 to 30 September 2011. 21 Dec 2011
Wellcome Trust publishes Annual Review 2011 The Wellcome Trust's Annual Review 2011 is now available, presenting a selection of our major activities and achievements in the year from October 2010 to September 2011. 21 Dec 2011
New candidate malaria vaccine neutralises parasite strains A new candidate malaria vaccine with the potential to neutralise all strains of the most deadly species of malaria parasite has been developed by a team led by scientists at the University of Oxford. 21 Dec 2011
ALCS and PLS provide innovative rights identification service for Wellcome Library digitisation project The Wellcome Library has embarked on a major programme to digitise its collection of key books relating to the history of modern genetics and make them available online for research purposes. 14 Dec 2011
Malaria during pregnancy: new study assesses risks during first trimester The largest ever study to assess the effects of malaria and its treatment in the first trimester of pregnancy has shown that the disease increases risk of miscarriage but that treatment is relatively safe. 14 Dec 2011
Rare genetic disorder provides clues to development of the pancreas A rare genetic disorder has given researchers a surprising insight into how the pancreas develops. The finding provides a clue to how it may be possible to 'programme' stem cells to become pancreatic cells. 12 Dec 2011
Changes in London taxi drivers' brains driven by acquiring 'the Knowledge' Acquiring 'the Knowledge' - the complex layout of central London's 25 000 streets and thousands of places of interest - causes structural changes in the brain and changes to memory in the capital's taxi drivers. 09 Dec 2011
Changing the locks: HIV discovery could allow scientists to block virus's entry into cell nucleus Scientists have found the 'key' that HIV uses to enter our cells' nuclei, allowing it to disable the immune system and cause AIDS. The finding provides a potential new target for anti-AIDS drugs. 09 Dec 2011
New international consortium to prepare research community for future pandemics An international consortium aiming to ensure that the clinical research community is better prepared for the next influenza pandemic or other rapidly emerging public health threat is launched today. 08 Dec 2011
Institutional Strategic Support Fund recipients announced The Wellcome Trust today announces the 23 UK universities that have received grants through its new funding scheme, a £19.75 million investment in academic biomedical research in the UK over the 2011/12 academic year. 08 Dec 2011
Royal prize for medical engineering pioneers The University of Leeds has been honoured with a Queen's Anniversary Prize for Higher and Further Education for its contribution to medical engineering. 05 Dec 2011
Wellcome Trust welcomes Government's Life Sciences Strategy and NHS innovation review The Director of the Wellcome Trust, Sir Mark Walport, has responded to the Government's Life Sciences Strategy and to the review of innovation in the NHS from NHS Chief Executive Sir David Nicholson. 05 Dec 2011
Study highlights serious problem of hospital-acquired infections in Africa Research funded by the Wellcome Trust suggests that bloodstream infections acquired while in care might contribute to one in every 20 deaths that occur in children in hospitals in sub-Saharan Africa. 30 Nov 2011
Initial Teacher Training can fail to equip science teachers with sufficient subject knowledge Many newly qualified science teachers complete their initial training without sufficient subject knowledge to teach, according to research commissioned and published by the Wellcome Trust. 29 Nov 2011
Wellcome Trust welcomes government investment in science education The UK government has announced further funding for Project ENTHUSE, matched by investment from the Wellcome Trust, to improve the quality of science teaching in schools. 29 Nov 2011
Funding boost for deep brain stimulation technology company A 3.5 million euro (£3 million) Strategic Translation Award has been granted to Sapiens Steering Brain Stimulation to support the development of next-generation deep brain stimulation technology. 29 Nov 2011
Skin cancer drug development boosted with £3m Strategic Translation Award The ICR and The Royal Marsden NHS Foundation Trust are to progress an experimental drug to combat the most deadly form of skin cancer into patient trials, with support from a Wellcome Trust Strategic Translation Award. 18 Nov 2011
Researchers discover new class of dual-acting antimalarial compounds A new class of dual-acting antimalarial compounds that target both the liver and the blood stage of the parasite's life cycle are described online today in 'Science'. 18 Nov 2011
Mark Henderson appointed Head of Communications at the Wellcome Trust Mark Henderson, Science Editor of 'The Times', is to join the Wellcome Trust as its new Head of Communications, it is announced today. 17 Nov 2011
Student organisation launched to encourage medical students to pursue careers in research An organisation to inform medical students about the benefits of careers in clinical research and academic medicine launches today, aiming to tackle the decline in the number of doctors pursuing careers in academic research. 15 Nov 2011
Researchers identify malaria's 'Achilles' heel' Researchers have revealed that the most deadly species of malaria parasite, Plasmodium falciparum, relies on a single receptor on the red blood cell's surface to invade, offering an exciting new focus for vaccine development. 11 Nov 2011
'Turn of Mind' by Alice LaPlante wins the Wellcome Trust Book Prize The third Wellcome Trust Book Prize has been awarded to Alice LaPlante for her debut novel 'Turn of Mind', a tale of a family's secrets exposed by murder and a brilliant mind in terminal decline. 10 Nov 2011
Scientists make step towards using brain scans to predict outcome of psychotic episodes Computer analysis of brain scans could help predict the future illness course of a patient with psychosis, which could allow doctors to make more accurate decisions about how best to treat patients. 08 Nov 2011
Editorial team announced for 'eLife' The senior editorial team is today announced for 'eLife', the new top-tier, open access research journal to be launched next year with the support of the Howard Hughes Medical Institute, the Max Planck Society and the Wellcome Trust. 07 Nov 2011
Malaria treatment approved for use by the EMA Eurartesim®, an artemisin combination therapy, has been approved by the European Commission for the treatment of uncomplicated malaria caused by the parasite Plasmodium falciparum. 03 Nov 2011
New antibiotic compound enters phase I clinical trial Novacta Biosystems has commenced dosing of the first healthy volunteers in a phase I clinical trial of a new antibiotic to treat the hospital superbug Clostridium difficile. 03 Nov 2011
Patient receives novel gene therapy for type of blindness The first patient to receive gene therapy for an incurable type of blindness was treated at the John Radcliffe Hospital in Oxford this week as part of a trial funded by the Health Innovation Challenge Fund. 31 Oct 2011
Professor Mike Ferguson appointed to Wellcome Trust Board of Governors The Wellcome Trust today announces the appointment of Professor Mike Ferguson, Dean of Research for the College of Life Sciences at the University of Dundee, to its Board of Governors. 31 Oct 2011
Wellcome Trust announces appointment of first Library Fellow The first appointment to a new fellowship scheme designed to support the Wellcome Library's transformation strategy has been announced: Dr Christine Aicardi is to pursue a research project on Francis Crick's career. 26 Oct 2011
Royal Society and Wellcome Trust partnership to nurture future world leaders in biomedicine Two of the world's most influential scientific organisations today launched the Sir Henry Dale Fellowships, a joint scheme to identify and support future world leaders in biomedical research. 25 Oct 2011
Roger go to yellow three: choral composition to explore the cocktail party effect Musicians are helping scientists to understand how our brains can focus listening attention amidst a room of background noise with performances of a new experimental choral composition. 24 Oct 2011
Brain scans support findings that IQ can rise or fall significantly during adolescence IQ, the standard measure of intelligence, can increase or fall significantly during our teenage years, and these changes are associated with changes to the structure of our brains. 20 Oct 2011
Outstanding new Wellcome Trust Investigators announced The Wellcome Trust today announces the latest recipients of its New and Senior Investigator Awards, given to outstanding researchers asking the most challenging research questions in biomedicine. 20 Oct 2011
Number of Facebook friends linked to size of brain regions Scientists funded by the Wellcome Trust have found a direct link between the number of 'Facebook friends' a person has and the size of particular brain regions. 19 Oct 2011
Video laryngoscope lands international distribution deal Makers of the McGrath video laryngoscope, Aircraft Medical, have landed a multi-million pound deal to distribute the latest model of the device to an international market. 18 Oct 2011
'Shock Head Soul' premieres at London Film Festival New film 'Shock Head Soul', supported by the Wellcome Trust, receives its UK premiere this week at the London Film Festival. 17 Oct 2011
First genome-wide association study for dengue identifies candidate susceptibility genes Researchers in South-east Asia have identified two genetic variants associated with increased susceptibility to severe dengue. The study offers clues to how the body responds to dengue infection. 17 Oct 2011
Google Earth typhoid maps reveal secrets of disease outbreaks Scientists working in Kathmandu, Nepal, have combined the latest in gene sequencing technology and global positioning system (GPS) case localisation to map the spread of typhoid and trace its source. 17 Oct 2011
Structural Genomics Consortium launches UK Biomedical Community Consultation The SGC is carrying out a consultation exercise to assess the level of convergence of priorities and interests between the SGC and UK biomedical research communities. 14 Oct 2011
Translation Award to develop cancer-attacking virus The Wellcome Trust has awarded up to £1.8 million to PsiOxus Therapeutics to support the development of a virus that attacks cancer cells. Clinical trials of the virus in patients are expected to begin in early 2012. 14 Oct 2011
New gene therapy corrects mutation in patient's stem cells For the first time, scientists have cleanly corrected a human gene mutation in a patient's stem cells. The result brings the possibility of patient-specific therapies closer tobecoming a reality. 13 Oct 2011
Winners announced for the first Wellcome Trust Science Writing Prize The winners of the inaugural Wellcome Trust Science Writing Prize, in association with the 'Guardian' and the 'Observer', have been announced. 13 Oct 2011
Mark Patterson named Managing Executive Editor of new open access journal Dr Mark Patterson, director of publishing at the Public Library of Science (PLoS), has been named managing executive editor of an open access research journal being launched next year. 11 Oct 2011
Scientists uncover the secrets behind rapid tissue repair UK researchers have discovered how cells detect and respond to tissue damage. Their findings could open up new opportunities for improving tissue repair in patients after illness or surgery. 10 Oct 2011
Brain imaging reveals why we remain optimistic in the face of reality For some people, the glass is always half-full. But why, in the face of clear evidence to the contrary, do some people remain so optimistic about the future? 10 Oct 2011
Miracles & Charms at Wellcome Collection Miracles & Charms, Wellcome Collection's autumn exhibition programme, opens today, linking faith, mortality and healing, and offering insight into human responses to chance and suffering. 06 Oct 2011
Wellcome Trust Book Prize 2011 shortlist announced The Wellcome Trust Book Prize today announces its third ever shortlist for works of fiction and non-fiction on the theme of health, illness or medicine. 06 Oct 2011
Wellcome Museum of Medical Science records opened to researchers Almost 40 boxes of records from the Wellcome Museum of Medical Science are newly catalogued and available to researchers in the Wellcome Library. 05 Oct 2011
Keeping track of reality: why some people are better at remembering A structural variation in the brain may explain why some people are better than others at distinguishing real events from those they may have imagined or been told about. 05 Oct 2011
New standard for HPV testing could improve diagnosis of head and neck cancers Researchers have identified the most accurate test for identifying HPV-related head and neck cancers. 04 Oct 2011
Scientists find mechanism that leads to drug resistance in bacteria causing melioidosis Researchers have identified how Burkholderia pseudomallei - the cause of melioidosis - develops resistance to the standard antibiotic treatment. 04 Oct 2011
Scientists test potential new treatment for most common form of infant leukaemia Scientists have demonstrated that a potential new drug could treat mixed-lineage leukaemia, the most common form of leukaemia in babies. 03 Oct 2011
Men develop diabetes at lower BMIs than women, study shows Men develop type 2 diabetes at a lower body mass index than women, according to clinical academics at the University of Glasgow. 03 Oct 2011
Structural Genomics Consortium announces $49 million new funding to search for new medicines The Structural Genomics Consortium has announced $48.9 million in new funding and that two new commercial partners have joined the Consortium. 29 Sep 2011
Film for chimps premieres in Liverpool The first film to be made expressly for chimpanzees receives its UK premiere at the Abandon Normal Devices Festival in Liverpool this weekend. 27 Sep 2011
Hedging your bets: how the brain makes decisions based on related information When making decisions based on interdependent factors, we choose based on how these factors correlate with each other and not using an ad hoc rule of thumb or through trial and error, as was previously thought. 23 Sep 2011
Is the 'longevity gene' nearing the end of its life? Sirtuins, proteins believed to significantly increase lifespan in a number of organisms - and the claimed target of some anti-ageing creams - do not, in fact, affect animal longevity, according to new research. 22 Sep 2011
Serotonin levels affect the brain's response to anger Fluctuations of serotonin levels in the brain, which often occur when someone hasn't eaten or is stressed, affect brain regions that enable people to regulate anger, according to a study part-funded by the Wellcome Trust. 21 Sep 2011
Scientists disarm HIV to prevent it damaging the immune system Researchers have found a way to prevent HIV from damaging the immune system in a new lab-based study. The research could have important implications for the development of HIV vaccines. 20 Sep 2011
Men and women fight infection differently, study suggests Female mammals are better prepared to fight infections and their bodies suffer less collateral damage when an infection does hit, according to a new study part-funded by the Wellcome Trust. 20 Sep 2011
Young people recognise the value of science for their future School pupils are interested in science at school and recognize that studying science could lead to a better career, according to a new report from the Wellcome Trust. 16 Sep 2011
Genetic variations in mice comprehensively catalogued Researchers have catalogued millions of genetic differences between 17 strains of mice. The result is a 'genetic blueprint' of variation in the mouse genome that will help drive forward our understanding of human biology. 15 Sep 2011
Artist Bobby Baker wins Mind Book of the Year 2011 Mental health charity Mind today presented performance artist Bobby Baker with its Book of the Year Award for 'Diary Drawings: Mental Illness and Me', a poignant visual documentary of mental ill-health and recovery. 14 Sep 2011
Surprising role for suppressive cytokine in antiviral immune responses A molecule normally implicated in restraining immune responses is also capable of stimulating defences against virus infection by promoting the survival of a population of immune cells known as natural killer cells. 14 Sep 2011
Scientists identify genes involved in storing fat Researchers using a mouse model have identified several genes that may lead to the unnecessary retention of fat. The study may explain why some people carry more weight than others, even when they have similar diets. 14 Sep 2011
Discovery of blood pressure genes could help prevent cardiovascular disease The new findings are a major advance in our understanding of the inherited influences on blood pressure and offer potential targets for the prevention of heart disease and stroke - the biggest cause of death worldwide. 12 Sep 2011
Babies more than two weeks premature show same brain responses to pain and touch Babies develop their ability to distinguish painful stimuli from general touch during the last two weeks of the normal gestation period, new research suggests. 09 Sep 2011
Genetic causes of rare eye disorder discovered Researchers have used next-generation DNA sequencing techniques to discover the genetic causes of a rare form of inherited eye disorder that leads to cataracts and glaucoma in young children. 09 Sep 2011
First large-scale review of medical history for 20 years is published Edited by Professor Mark Jackson, 'The Oxford Handbook of The History of Medicine' celebrates the richness and variety of medical history around the world. 08 Sep 2011
Scientists create mammalian cells with single chromosome set For the first time, researchers have created mammalian cells containing a single set of chromosomes. The technique should allow scientists to better establish the relationships between genes and their function. 08 Sep 2011
Malaria prevention strategies could substantially cut killer bacterial infections Interventions targeting malaria, such as insecticide-treated bed nets, antimalarial drugs and mosquito control, could substantially reduce cases of bacteraemia, which kill hundreds of thousands of children each year. 07 Sep 2011
Study of metabolites reveals genetic influence on human metabolism Researchers have undertaken the most comprehensive investigation of genetic variance in human metabolism and discovered new insights into a range of common diseases. 01 Sep 2011
Gene 'overdose' significantly increases risk of extreme thinness Scientists have discovered a genetic variant that makes men 23 times and women five times more likely to be underweight. The finding, reported today in the journal 'Nature', affects one in 2000 people. 01 Sep 2011
Scientists develop new technology to help understand bacterial infections Scientists from the University of Bristol have developed a new approach for studying molecules within their natural environment, a technique that will help researchers understand how bacteria infect our cells. 31 Aug 2011
Six new genetic variants linked to type 2 diabetes discovered in South Asians An international team of researchers led from Imperial College London has identified six new genetic variants associated with type 2 diabetes in South Asians. 30 Aug 2011
Research offers new way to target shape-shifting proteins Researchers at the University of Leeds have found that an antibiotic molecule can stop the formation of amyloid fibrils, the long protein strands that cause joint pain in people receiving kidney dialysis. 30 Aug 2011
Third genetic link to osteoarthritis discovered Researchers have identified a gene that is associated with osteoarthritis with the help of data from the 1000 Genomes Project. 26 Aug 2011
Immunising at birth is safe and effective against severe pneumococcal disease Vaccinating children against the pneumococcus at birth is safe and primes the immune system against later infection, according to new research. 26 Aug 2011
Gene-therapy success for children born without functioning immune system Researchers at the UCL Institute of Child Health have developed gene-therapy programmes that can successfully treat children born with an inability to fight infections. 25 Aug 2011
Researchers produce complete map of gene activity in the mouse brain A complete map of active genes in a mammalian brain has been produced for the first time by scientists at the University of Oxford and the US National Human Genome Research Institute. 25 Aug 2011
Source of cholera pandemic revealed Researchers have used next-generation sequencing to trace the source and explain the spread of the latest cholera pandemic, highlighting the impact of antibiotic resistance. 25 Aug 2011
Women and men anticipate negative experiences differently, study suggests New research suggests that men and women differ in the way they anticipate an unpleasant emotional experience, and that this influences the effectiveness with which the experience is committed to memory. 24 Aug 2011
New research reveals how nerve cells protect themselves against stroke damage Scientists have identified a mechanism in some of the brain's nerve cells that protects them from damage during the onset of stroke. The findings could be used to protect other nerve cell types responsible for speech and movement. 18 Aug 2011
Wellcome Trust appoints new Head of Education and Learning Dr Hilary Leevers has been appointed as Head of Education and Learning at the Wellcome Trust. Dr Leevers will lead the delivery of the Trust's recently announced education strategy. 16 Aug 2011
Winners of Master's Awards in Medical History and Humanities announced The first successful applicants for the Wellcome Trust Master's Awards were announced today, supporting the brightest minds in the History of Medicine or Medical Humanities. 15 Aug 2011
Wellcome Trust Science Writing Prize 2011: Shortlist announced The Wellcome Trust today reveals the shortlist for its inaugural Science Writing Prize in association with the 'Guardian' and the 'Observer'. 12 Aug 2011
New research could reveal how oestrogen helps protect women from cardiovascular disease The sex hormone oestrogen could help protect women from cardiovascular disease by keeping the body's immune system in check, new research from scientists at Queen Mary, University of London, suggests. 12 Aug 2011
Multiple sclerosis research doubles the number of genetic variants associated with the disease Scientists have identified 29 new genetic variants linked to multiple sclerosis, providing key insights into the biology of this debilitating neurological disease; many of the genes implicated are relevant to the immune system. 11 Aug 2011
Egg's movements predict embryo's chance of survival, study suggests Researchers at the University of Cambridge have developed a new technique that could significantly increase success rates of pregnancies and reduce the frequency of multiple pregnancies associated with IVF. 10 Aug 2011
Brain's map of space falls flat when it comes to altitude The brain's 'map' of space may be surprisingly two-dimensional and unable to accurately register our altitude, according to new research funded by the Wellcome Trust. 08 Aug 2011
Text message reminders improve healthcare practice in rural Africa, study finds New research funded by the Wellcome Trust has shown that sending text message reminders to healthcare workers in rural Africa can improve the implementation of national guidelines for treating malaria. 04 Aug 2011
Wellcome Trust statement on the Olympic Park The Wellcome Trust is disappointed that the Government and the Mayor of London did not wish to take our proposals for the Olympic Park further. If our bid had been successful, our holistic vision for the Olympic Park and the legacy would have delivered a world-class centre for technology and innovation and up to 7000 high-quality new jobs, and it would have made a substantial contribution to the regeneration of East London. 04 Aug 2011
Wellcome Trust statement on the Government response to the Hargreaves review The Wellcome Trust is pleased that the Government has accepted the recommendations of the Hargreaves review of intellectual property. We believe the actions proposed are crucial to address the barriers that the UK's outdated copyright system presents to research and innovation. 04 Aug 2011
European Bioinformatics Institute to lead UK PubMed Central The European Molecular Biology Laboratory's European Bioinformatics Institute (EMBL-EBI) has been awarded the contract to run UK PubMed Central (UKPMC), the free online life science literature resource. 29 Jul 2011
Historic Arabic medical manuscripts go online Researchers may now search and browse the Wellcome Library's Arabic manuscripts using groundbreaking functionalities in a new online resource that brings together rich descriptive information and detailed images. 28 Jul 2011
Biomedical research funders respond to the Review of Research Using Non-Human Primates The Biotechnology and Biological Sciences Research Council (BBSRC), Medical Research Council (MRC) and Wellcome Trust have responded to the independent review led by Professor Sir Patrick Bateson FRS. 27 Jul 2011
Drug shown to improve sight for patients with inherited blindness A hereditary sight loss condition has been reversed with a drug for the first time, giving some patients, legally certified as blind, useful vision to improve their everyday lives. 26 Jul 2011
Call for clear HIV prevention messages in South Africa Scientists at the University of KwaZulu-Natal's Africa Centre for Health and Population Studies say there is a need for "straightforward, unambiguous messages" about the risk that having multiple sexual partnerships poses for HIV transmission. 26 Jul 2011
Sainsbury Wellcome Centre granted planning permission Plans to build a new neuroscience research centre have been approved by London Borough of Camden, subject to referral to the Mayor. 25 Jul 2011
New report examines the use of animals containing human material in biomedical research A new report looking at the use of animals containing human material (ACHM) in biomedical research calls for additional oversight to ensure innovative science can flourish within ethical boundaries with public support. 22 Jul 2011
Most accurate genetic map to date is published You can't use this map to find out where you're going, but it does tell us a lot about where we came from: it's the world's most advanced human genetic map, as constructed by a consortium of scientists. 21 Jul 2011
Wellcome Trust announces Engagement Fellows The Wellcome Trust is pleased to announce the first recipients of its Engagement Fellowships: clinical scientist Kevin Fong and medical historian Richard Barnett. 19 Jul 2011
Minister launches key phase of bioincubator development Rt Hon David Willetts MP visited the Stevenage Bioscience Catalyst site yesterday to perform a topping-out ceremony, a symbolic celebration of laying the final portion of cement in a building's construction. 15 Jul 2011
Genome analysis provides evolutionary insights into exodus out of Africa African and non-African populations continued to interbreed long after the evolutionary exodus out of Africa 60 000 years ago, according to a new study from researchers at the Wellcome Trust Sanger Institute. 14 Jul 2011
New journal editor named as Randy Schekman Randy Schekman, a distinguished cell biologist and the 14th editor of 'Proceedings of the National Academy of Sciences', has been named the first editor of a new journal that the Howard Hughes Medical Institute, the Max Planck Society and the Wellcome Trust aim to launch next year. 12 Jul 2011
Unlocking the genetics and biology of ankylosing spondylitis A study involving more than 5000 people with ankylosing spondylitis has identified a series of genetic variants associated with increased susceptibility to the condition and provided new clues to how it may be treated in the future. 11 Jul 2011
Beauty is in the medial orbitofrontal cortex of the beholder, study finds A region at the front of the brain 'lights up' when we experience beauty in a piece of art or a musical excerpt, according to new research funded by the Wellcome Trust and published today in the open access journal PLoS One. 07 Jul 2011
Researchers' discovery of why sunburn hurts reveals possible target for new pain relief drugs Researchers have found a molecule that controls sensitivity to pain from UVB irradiation, identifying it as a new target for medicines to treat pain caused by other common inflammatory conditions. 07 Jul 2011
'Smart Cane' gets Wellcome Trust support to aid the visually challenged The Wellcome Trust has awarded almost £450 000 to the Indian Institute of Technology Delhi, under the R&D for Affordable Healthcare in India initiative, to further develop a navigational mobility aid for the visually challenged. 06 Jul 2011
Shrinking brain could aid diagnosis of clinical depression Parts of the brain appear to shrink when people suffer from severe depression, according to research funded by the Wellcome Trust and the National Institute for Health Research. 05 Jul 2011
Translation Award to develop cow vaccine for deadly disease The Wellcome Trust has awarded a £1 million Translation Award to an international consortium of researchers to develop a new vaccine for a deadly disease of cattle and buffalo in India. 04 Jul 2011
Rogue blood cells may contribute to post-surgery organ damage Research supported by the Wellcome Trust has shed light on why serious trauma or major surgery can lead to organ damage in seemingly unconnected parts of the body. 29 Jun 2011
Leading research organisations announce top-tier, open access journal for biomedical and life sciences The Howard Hughes Medical Institute, the Max Planck Society and the Wellcome Trust announced today that they are to support a new, top-tier, open access journal for biomedical and life sciences research. 27 Jun 2011
Award recognises Wellcome Trust's commitment to translational research The Wellcome Trust has been awarded the 'Most Significant Contribution to the Sector' at the European Mediscience Awards, 2011. 27 Jun 2011
Premature ageing caused by some HIV drugs, study shows A class of antiretroviral drugs commonly used to treat HIV, particularly in Africa and low-income countries, may cause premature ageing by damaging DNA in the mitochondria. 27 Jun 2011
Robotics award for i-Snake® team The research team behind a robotic snake-like device for surgery called i-Snake® have won a prestigious award at the IEEE International Conference on Robotics and Automation. 24 Jun 2011
Fellowship programme for newly qualified postdoctoral researchers extended following scheme's success Seventeen of the brightest newly qualified postdoctoral researchers have been awarded Sir Henry Wellcome Postdoctoral Fellowships, and the scheme itself has been extended indefinitely. 24 Jun 2011
TB trial highlights challenges of introducing new childhood vaccine A new vaccine to combat tuberculosis is less effective at stimulating an immune response when administered to Gambian infants in combination with the routine immunisation schedule. 23 Jun 2011
3D picture of histamine receptor may lead to improved antihistamines An international team of scientists using Diamond Light Source, the UK's national synchrotron facility, has successfully solved the complex 3D structure of the human histamine H1 receptor protein. 23 Jun 2011
Any questions? Inside 'I'm A Scientist...' A Wellcome Trust-supported event employs a reality-TV-style twist, giving students live and direct access to scientists - whom they then vote out one by one. 16 Jun 2011
Researchers create a knockout resource for mouse genetics An international consortium of researchers has knocked out almost 40 per cent of the genes in the mouse genome in embryonic stem cells. 16 Jun 2011
Weight at age 18 linked to cancer in men decades later Public health researchers have identified a link between men being overweight or obese at age eighteen and death from cancer in later life. 16 Jun 2011
Guiding light: how the brain gets wired for stereo vision Nerve cells that transmit light signals from the eye use a molecule best known for its role in blood vessel growth as a 'stepping stone' to help them reach the opposite brain hemisphere. 15 Jun 2011
Public view cash incentives for health goals as unfair Members of the UK and US public disapprove of using cash incentives to spark changes in health behaviours among patients and deem these methods to be unfair, according to a new study. 14 Jun 2011
Proposed changes to the Health and Social Care Bill are a step in the right direction, says Wellcome Trust The government's latest statement on the proposed health reforms is an important step towards ensuring that the new health system supports and promotes research. 14 Jun 2011
Many migraines might have a common genetic basis A study into the genetic basis of many common forms of migraine has identified three variants that suggest that most forms of migraine have a shared genetic foundation, regardless of how they manifest. 13 Jun 2011
We are all mutants Each one of us receives approximately 60 new mutations in our genome from our parents, according to the first-ever direct measure of new mutations coming from mother and father. 13 Jun 2011
Imaging the brain in a blackout Researchers developing a new brain imaging technique have, for the first time, been able to watch what happens to the brain as it loses consciousness. 13 Jun 2011
Outstanding researchers receive inaugural Wellcome Trust Investigator Awards The Wellcome Trust today announces the first recipients of its Investigator Awards, £56 million worth of funding for exceptional researchers addressing the most important questions about health and disease. 02 Jun 2011
Applications open for Medical Humanities Investigator Awards Applications open today for world-class scholars in the medical humanities and bioethics to apply for Wellcome Trust Investigator Awards in Medical Humanities. 01 Jun 2011
How our focus can silence the noisy world around us How can someone with perfectly normal hearing become deaf to the world around them? New research suggests that focusing on a task results in the experience of deafness to perfectly audible sounds. 27 May 2011
African trial questions emergency treatment of children in shock Giving fluids rapidly through a drip as an emergency treatment for African children suffering with shock from severe infections does not save lives, according to a major clinical trial. 27 May 2011
Polypill halves predicted heart disease and stroke risk The world's first international polypill trial has shown that a four-in-one combination pill can halve the predicted risk of heart disease and stroke. 26 May 2011
A new name for UKCMRI The UK Centre for Medical Research and Innovation (UKCMRI) is to be renamed 'The Francis Crick Institute' in honour of one of the United Kingdom's greatest scientists. 25 May 2011
The Rap Guide to Evolution launches An online series of rap music videos to aid the teaching of evolution in schools launches in London tonight. 25 May 2011
Director of the Wellcome Trust elected Fellow of the Royal Society The Royal Society today announced the election of 44 new Fellows, who this year include Sir Mark Walport, Director of the Wellcome Trust, together with seven other notable Trust-funded researchers. 20 May 2011
Cell therapy to prevent transplant rejection shows promise A cell therapy that could prevent transplanted organs being rejected and remove the need for the prolonged use of immunosuppressant drugs has shown promise in early-stage mouse studies. 20 May 2011
Wellcome Trust calls for clearer vision for NHS reform The government's proposed reforms to the National Health Service lack a clear vision of what a 21st-century health service should deliver, according to the Director of the Wellcome Trust, Sir Mark Walport. 20 May 2011
Rare tumour's 'fingerprint' used to develop cheap and reliable new test Researchers at the University of Oxford have developed a cheap and reliable diagnostic test for a rare form of cancer. The test involves screening tumour samples for a particular molecular fingerprint unique to this type of cancer. 20 May 2011
Wellcome Trust welcomes Hargreaves Review on reform of UK copyright system The Wellcome Trust supports the recommendations of the Hargreaves Review for reform of the UK copyright system. Such reform is urgently needed to update a system that is no longer fit for purpose in the digital age. 18 May 2011
Rare surgeon portrait acquired by Wellcome Library The Wellcome Library in London has acquired a magnificent portrait drawing of the French surgeon Ange-Bernard Imbert-Delonnes (1747-1818) by Pierre Chasselat - a portrait with a distinctive feature. 18 May 2011
'Master regulator' gene for obesity and diabetes discovered Researchers have found that a gene linked to type 2 diabetes and cholesterol levels acts as a 'master regulator', controlling the behaviour of other genes found within fat tissue in the body. 16 May 2011
'After the Apocalypse': a film about cleaning up after nuclear experimentation Should people with birth defects be prevented from having children and passing on their defective genes? This question is at the heart of a moving documentary receiving its world premiere in London tonight. 11 May 2011
New installation, Reflex, at the Wellcome Trust People walking along Euston Road will encounter an unusually arresting reflection of themselves in a new light installation, 'Reflex', created by rAndom International. 09 May 2011
Scientists track evolution of deadly fungus, one of the world's major killers Research has shed light on the origins of a fungal infection that is one of the major causes of death from AIDS-related illnesses. The study shows how Cryptococcus neoformans evolved and spread out of Africa and into Asia. 05 May 2011
Diamond x-rays uncover structure of tooth decay enzymes Scientists using Diamond Light Source, the UK's national synchrotron science facility, have helped solve the 3D structure of an enzyme that plays a key part in tooth decay caused by sugar. 04 May 2011
Wellcome Trust expands Investigator Awards to tackle ambitious questions in medical humanities The Wellcome Trust announces today that it will expand its new Investigator Awards to cover the medical humanities and bioethics, inviting applications from world-class scholars asking the most important questions at the interface of science, medicine and the humanities. 04 May 2011
Trial recommends new antibiotic for typhoid in low-income countries A large clinical trial comparing treatments for typhoid has recommended the use of gatifloxacin, an affordable new-generation antibiotic. 03 May 2011
Final child vaccinated in clinical trial of new TB vaccine The final participant in a clinical trial to assess the safety and efficacy of a new vaccine against tuberculosis (TB) has been vaccinated. 03 May 2011
Major malaria study leads WHO to revise treatment guidelines The results of the largest ever clinical trial among patients hospitalised with severe malaria have led the World Health Organisation (WHO) to revise its guidelines for the treatment of the disease in African children. 27 Apr 2011
UK's first Science Garden to be built in Birmingham A water fountain powered by natural energy, a man-sized hamster wheel and an 8m high interactive sculpture are some of the features of a new Science Garden that is to be built outside ThinkTank, Birmingham Science Museum. 21 Apr 2011
Animal model suggests simple injection could limit damage from heart attacks and strokes Research published this week could pave the way for new treatments to reduce the tissue and organ damage that follows the loss of blood supply in heart attacks and strokes, and could improve the outcome of transplant surgery. 20 Apr 2011
UK Government urged to permit use of techniques to prevent transmission of mitochondrial diseases Leading medical research charities have signed a joint open letter to the Secretary of State for Health, the Rt Hon Andrew Lansley MP, urging him to introduce regulations to enable research techniques developed to prevent the hereditary transmission of mitochondrial disease to be used. 20 Apr 2011
Persistence of stuttering into teenage years predicted by simple model Researchers have developed a model that can predict whether a child will recover from a stutter in four out of five cases. The model should allow clinicians to target those children most in need of speech therapy. 18 Apr 2011
Womb cancer genome scan reveals prostate cancer link The first genome scan for womb cancer has revealed a genetic region that is associated with a reduced risk of the disease. The same region, called HNF1B, has been linked previously to lower prostate cancer risk in men. 18 Apr 2011
£2.5 million collaboration to explore MRI for newborn intensive care The Wellcome Trust has awarded a Strategic Translation Award worth almost £2.5 million to GE Healthcare to investigate the use of MRI for newborns at high risk of brain injury. 13 Apr 2011
Device launched to improve weight loss surgery Irish company Crospon have announced the launch of a new tool, an imaging catheter called the EF-620, to improve the outcome of weight loss surgery. 12 Apr 2011
Glasgow Science Centre secures support for new exhibition A brand new exhibition at Glasgow Science Centre is to become a reality thanks to support from the Wellcome Trust and GlaxoSmithKline. The exhibition, on the science of human health, is due to open in 2012. 11 Apr 2011
Mapping the brain: new technique poised to untangle the complexity of the brain Scientists have moved a step closer to being able to develop a computer model of the brain after developing a technique to map the connections and functions of nerve cells in the brain together for the first time. 11 Apr 2011
Monkeys provide malaria reservoir for human disease in South-east Asia Monkeys infected with an emerging malaria strain are providing a reservoir for human disease in South-east Asia, according to research published today. The study confirms that the species has not yet adapted to humans. 08 Apr 2011
Wellcome Trust launches new Science Writing Prize The Wellcome Trust has launched a new Science Writing Prize, in association with the 'Guardian' and the 'Observer'. 07 Apr 2011
Heading for the Open Road: costs and benefits of transitions in scholarly communications A report published today looking at how to improve access to academic literature suggests that open access is likely to have the greatest benefits to the UK scholarly communications system. 07 Apr 2011
Comprehensive approach to hospital care improves survival rates for Kenyan children New research in Kenya has demonstrated that addressing deficiencies in clinical knowledge and hospital organisation results in improvements in medical practice for young children in rural areas. 06 Apr 2011
Five new genetic variants linked to Alzheimer's disease Researchers have identified five new genetic variants that increase the risk of developing Alzheimer's disease, bringing the total number of known variants linked to the disease to ten. 04 Apr 2011
New clues to why nerve cells fail to grow in scar tissue A new study has shown how the battle between two competing molecules can determine whether nerve cells grow and migrate or whether they are inhibited, severely limiting recovery from damage. 04 Apr 2011
Twenty years of the Children of the 90s Children of the 90s is celebrating 20 years of vital research - and is now embarking on a study of the children of the original Children of the 90s. 01 Apr 2011
Brain scans reveal differences in brain structure in teenagers with severe antisocial behaviour Brain scans of aggressive and antisocial teenage boys with conduct disorder have revealed differences in the structure of the developing brain that could link to their behaviour problems. 01 Apr 2011
Researchers to develop new approaches to tackle blindness, leukaemia and muscular dystrophy Oxford University researchers have been awarded £4.4 million for the development of innovative medical technologies and treatments under the Health Innovation Challenge Fund. 31 Mar 2011
Researchers find the genetic processes that drive acute myeloid leukaemia Researchers have described how the most common gene mutation in acute myeloid leukaemia starts the process of cancer development and how it can cooperate with other mutations to cause full-blown leukaemia. 30 Mar 2011
Severe reaction to epilepsy drug linked to genetic variant Researchers have discovered a genetic variant that significantly increases the risk of carriers being allergic to a common medication for epilepsy. 24 Mar 2011
Translation Award to tackle muscle spasms A Translation Award of up to £1.75 million from the Wellcome Trust will support development of a drug to treat the debilitating muscle spasms associated with multiple sclerosis and potentially other disorders. 23 Mar 2011
New project aims to unlock genetic changes behind developmental disorders A new nationwide project aiming to improve the care and diagnosis of developmental disorders and understand their relation to the human genome is announced today. 22 Mar 2011
Protein find could offer new candidate for TB vaccine Scientists have discovered a protein produced by tuberculosis (TB) bacteria that could be the key to a new vaccine for the disease. The current vaccine is not very effective, and new treatments are needed to combat the disease. 22 Mar 2011
Study reveals genetic clues to chronic liver disease The first results from the Wellcome Trust Case Control Consortium 3 have revealed 15 new genomic regions affecting a person's risk of developing the chronic liver disease primary biliary cirrhosis. 18 Mar 2011
Scientists find new clues to how immune cells operate Researchers have identified control mechanisms that allow certain white blood cells, which play a vital part in fighting viral infections and dealing with organ transplants, to carry out their work. 17 Mar 2011
Statement regarding Olympic Park proposal The Wellcome Trust has been shortlisted by the Olympic Delivery Authority to submit a proposal for the purchase and long-term management of the residential properties known as the Athletes Village. 17 Mar 2011
Why Henry Higgins could tell his barrow girl from his fair lady When Professor Higgins instructed Eliza Doolittle that it was "Ay not I", he was drawing on years of experience as a professor of phonetics - but his ability to differentiate between similar sounds may have stemmed from birth. 16 Mar 2011
Treatments for recurring TB infection failing the developing world, study finds The standard approach to re-treating tuberculosis (TB) in low- and middle-income settings is failing, according to research funded by the Wellcome Trust. 16 Mar 2011
Gene linked to peanut allergy An international collaboration led by researchers at the University of Dundee has discovered a genetic link to peanut allergy. The study marks the first robust evidence pinpointing a specific gene. 11 Mar 2011
Beat it: how the brain perceives rhythm The brain uses distinct timing mechanisms to measure the duration between the intervals in a sequence of sounds, and researchers have found that distinct parts of the brain are involved in the these timing mechanisms. 10 Mar 2011
'Ars Moriendi: the art of dying' at Wellcome Collection now Joanna Walsh's 'Ars Moriendi: the art of dying' is an artwork being created in the foyer space of Wellcome Collection, exploring our relationship with death through personal and quietly affecting drawings. 08 Mar 2011
Studies double the known genetic links to coronary heart disease Researchers have discovered 17 new genetic variants linked with increased heart disease risk. The research more than doubles the known genetic links to coronary heart disease, which kills 88 000 people in the UK every year. 07 Mar 2011
Researchers step towards a non-invasive test for Down's syndrome A new, non-invasive, method to diagnose Down's syndrome during pregnancy is described this week in 'Nature Medicine'. A larger study is needed to confirm the findings, but results suggest that the test is accurate. 07 Mar 2011
New imaging technique tracks cardiovascular disease in mice An exciting non-invasive imaging technique that tracks the build-up of plaque in arteries, the main cause of cardiovascular disease leading to heart attack and stroke, is described online in 'Nature Medicine'. 04 Mar 2011
Strategic Award supports The Battle of Ideas festival and Debating Matters The Institute of Ideas has received an £875 000 Wellcome Trust Strategic Award to support the development of its two flagship projects - The Battle of Ideas festival and the Debating Matters competition - over a five-year period. 03 Mar 2011
Depression after miscarriage can continue even after healthy birth Women who experience depression and anxiety after a miscarriage continue to experience these symptoms even if they subsequently go on to have a healthy child, according to a study of pregnant women from ALSPAC. 03 Mar 2011
Genetic disease keeps sufferers unhealthily thin It is well understood that excess body fat can be detrimental to health. Having too little fat, however, can also be damaging. New research from the University of Cambridge Metabolic Research Laboratories has revealed a rare condition that prevents people producing fat cells correctly. 02 Mar 2011
Diabetes drug improves survival from life-threatening melioidosis infection A study funded by the Wellcome Trust has identified a diabetes drug that halves the mortality rate from a deadly infectious disease found throughout South-east Asia and Northern Australia. 01 Mar 2011
New antibody therapy to tackle tuberculosis A new study describes an antibody-based therapy that protects against tuberculosis infection in mice and could lead to new treatments for tuberculosis in humans. 28 Feb 2011
Discovery of new gene mutation in schizophrenia offers a new target for drug therapies An international team of scientists has identified a gene mutation strongly linked to schizophrenia that may be an important target for the development of new drug therapies. 24 Feb 2011
Caught in the act: trypanosome sex visualised for the first time Researchers at the University of Bristol have observed trypanosome sex taking place inside the parasite's tsetse fly carrier. 22 Feb 2011
Malaria parasites shun sex when nutrients are low When food is scarce, many animals need to choose when to conserve energy and survive and when to spend energy reproducing. New research from the University of Edinburgh shows that malarial parasites gather information from their environment to strike a balance between the two. 18 Feb 2011
Researchers characterise rare immune disorder Researchers at Newcastle University are among the first in the world to characterise a rare syndrome that devastates the immune system and can lead to hereditary leukaemia and lung disease. Their findings are already helping to inform life-saving treatment for patients. 18 Feb 2011
Science Dogme: a manifesto for science, technology and medicine exhibitions In this month's 'Museums Journal', Ken Arnold, Head of Public Programmes at Wellcome Collection, and Thomas Söderqvist, Director of the Medical Museion Copenhagen, publish a provocative Dogme-style manifesto of 17 rules for creating inspiring science, technology and medicine exhibitions. 17 Feb 2011
Dad's genes direct mum's cells to nourish baby during pregnancy A new study in mice reveals how a mother's immune system helps to nourish her growing fetus, with help from the father's genes. The findings may provide insights into pregnancy disorders in humans, such as pre-eclampsia and recurrent miscarriage. 16 Feb 2011
Fear of infection leads to huge decline in HIV rates in Zimbabwe In the ten years leading to 2007, Zimbabwe saw a dramatic fall in the number of people infected with HIV. New research has shed light on how mass social change driven by greater awareness led to this unexpected downturn. 11 Feb 2011
HIV-uninfected babies born to mothers with HIV have fewer antibodies, study shows Babies whose mothers have HIV, but who are not HIV positive themselves, are born with fewer antibodies - which fight infection - than babies not exposed to HIV, a new study has found. 09 Feb 2011
Exposure to worm infection in the womb may protect against eczema, study suggests Exposure to worm infections in the womb may protect a newborn infant from developing eczema, a study funded by the Wellcome Trust suggests. A large trial in Uganda showed that treating a pregnant woman for worm infections increased her child's chances of developing the allergic skin disease. 31 Jan 2011
Study shows how bacteria keep ahead of vaccines and antibiotics Bacteria have the uncanny ability to quickly evolve, and large-scale genome sequencing of the bacterium Streptococcus pneumoniae has now revealed the patterns of genomic adaptation required for it to develop drug resistance. 28 Jan 2011
The time of our lives: researchers identify ancient mechanism behind our body clocks The mechanism that controls the 24-hour internal clock found in all organisms, from photosynthetic algae to humans, has been identified by Wellcome Trust-funded researchers. 27 Jan 2011
Protection of pregnant women against malaria remains inadequate Methods to protect pregnant women from malaria are still underutilised in sub-Saharan Africa, according to a study published today in 'Lancet Infectious Diseases'. 26 Jan 2011
Working towards an improved rotavirus vaccine for the developing world The MSD Wellcome Trust Hilleman Laboratories announced today that the organization's first project will be a feasibility study into how new technologies might be used to develop a rotavirus vaccine designed specifically with developing country needs in mind. 25 Jan 2011
£1 million Strategic Award to spark debate on advances in biomedical research Y Touring, an award-winning national touring theatre company, has been awarded almost £1 million by the Wellcome Trust to support a five-year project on biomedical research and its implications for human health. 24 Jan 2011
Their finest hour: Lord Moran papers open for study A series of papers by Sir Charles Wilson, the personal physician of Winston Churchill, have been opened for study at the Wellcome Library. 21 Jan 2011
Larynx transplant restores woman's ability to speak after eleven years A pioneering transplant, developed with funding from the Wellcome Trust, has restored the voice of a woman who had lost the ability to breathe on her own and had not spoken for eleven years. 21 Jan 2011
Gene find gives new clues to kidney cancer A gene that is mutated in one in three people with the most common form of kidney cancer has been identified, bringing new insights into the biology of the disease and revealing possible opportunities for treatment. 20 Jan 2011
Kymab research and development facility opens in Cambridge The Cambridge research and development facility of Kymab, a biopharmaceutical company developing a next-generation human-mouse therapeutic antibody platform, was formally opened yesterday by Sir Mark Walport, Director of the Wellcome Trust, and Sir Paul Nurse, President of the Royal Society. 19 Jan 2011
Seeding Drug Discovery-funded company announces licensing deal with GSK UCL spin-out company Pentraxin has this week licensed another of its drug development programmes to GlaxoSmithKline. The programme was initially supported by a Seeding Drug Discovery award from the Wellcome Trust. 18 Jan 2011
Roger Brownsword appointed Chairman of UK Biobank Ethics and Governance Council Professor Roger Brownsword has been appointed as Chairman of the UK Biobank Ethics and Governance Council. He replaces Professor Graeme Laurie, who finished his four-year term at the end of 2010. 12 Jan 2011
Global funding agencies commit to enhancing access to research data to improve public health Health research data must be made more widely available within the scientific community if we are to unlock the full potential of research and achieve significant advances in public health, according to leading funding agencies. 10 Jan 2011
Brain scans show children with ADHD have faulty off-switch for mind-wandering Brain scans of children with attention deficit hyperactivity disorder (ADHD) have shown for the first time why people affected by the condition sometimes have such difficulty in concentrating. 06 Jan 2011
Chronic fatigue syndrome not caused by XMRV virus, study shows A virus previously thought to be associated with chronic fatigue syndrome is not the cause of the disease, a detailed study has shown. 06 Jan 2011
Pregnant, constipated and bloated? Fly poo may tell you why Clues about how our gut helps to regulate our appetite have come from a most unusual source: fruit fly faeces. Scientists at the University of Cambridge are using the fruit fly to understand aspects of human metabolism, including why pregnant women suffer from bloating and constipation, and even the link between a low-calorie diet and lifespan. 06 Jan 2011
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