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Showcase

A history and evaluation of the Showcase scheme

Showcase was established to promote high-risk, adventurous research in 1996, to commemorate the 60th anniversary of the founding of the Wellcome Trust. The scheme is currently suspended.

The grantholders' names are grouped alphabetically by surname.

| A | B | C | F | G | H | L | M | P | Q | S | T | U | V | W |

A

Dr S Al-Damluji
Department of Medicine, Royal Free Hospital School of Medicine
A novel mechanism of action of antidepressants

Professor J H Anstee
Department of Biological Sciences, University of Durham
A model to test the concept of immunological control of haematophagous insect vectors of disease

B

Professor A E Bianco
Department of Parasitology, Liverpool School of Tropical Medicine
DNA vaccines for carbohydrate antigens

Dr S Britland
School of Pharmacy, University of Bradford
Towards 'smart dressings' for wound repairs

C

Professor T Chard
Department of Chemical Pathology, Reproductive Physiology Laboratory, St Bartholomew's and Royal London School of Medicine
Peritoneal dialysis with specific antibodies

F

Professor C Ffrench-Constant
Department of Medical Genetics, University of Cambridge
Analysis of the signalling mechanisms responsible for integrin-mediated survival and migration in oligodendrocytes using cell permeable homeopeptides

Professor A J Freemont
Musculoskeletal Research Group, University of Manchester
Use of autologous cells infected with recombinant adenovirus to study chondrolysis in human invertebral discs

G

Professor S J Gaskell
Michael Barber Centre for Mass Spectrometry, University of Manchester Institute for Science and Technology (UMIST)
Miniaturised techniques for proteome analysis

Professor C D Gregory
School of Biomedical Sciences, University of Nottingham
Further studies of apoptotic cell surfaces using a recombinant phage antibody library

H

Dr I N Hampson
Department of Obstetrics and Gynaecology, University of Manchester
The Serum Epitope Comparative Technique (SECT)

Dr A W Heath
Division of Molecular and Genetic Medicine, University of Sheffield Medical School
Fusion proteins with enhanced immunogenicity

Dr G F Hoyne
Respiratory Medicine Unit, University of Edinburgh
Notch-notch ligand interactions between T cells and APCs

L

Dr Bethan Lang
Institute of Molecular Medicine, University of Oxford
Epilepsy: a search for serum antibodies

M

Dr J T Manning
School of Biological Sciences, University of Liverpool
The second to fourth digit ratio and risk of myocardial infarction

Dr G M Matthews
Department of Surgery, University of Birmingham
The molecular basis of oxygen sensing

Dr C D McCaig
Department of Biomedical Sciences, University of Aberdeen
Orienting cell division

Dr A J Morton
Department of Pharmacology, University of Cambridge
Nuclear inclusion formation in real time

P

Dr T A Paget
Department of Biological Sciences, University of Hull
Apoptosis: a novel approach for the control of protozoan parasites

Dr N Peters
Academic Cardiology Unit, National Heart and Lung Institute, Imperial College School of Medicine
Transduction of skeletal muscle cells with the connexin43 gene for incorporation into the functional myocardial syncytium: a potential therapy for the arrhythmic and failing heart

Dr J C Pickup
Department of Chemical Pathology, Guy's Hospital Medical School, UMDS of Guy's and St Thomas' Hospital
with
Professor D J S Birch

Department of Physics and Applied Physics, University of Strathclyde
Single and multiphoton-excited skin surface fluorescence for non- invasive metabolic monitoring of diabetes mellitus

Q

Dr J P Quinn
Department of Veterinary Pathology, Royal (Dick) School of Veterinary Studies, University of Edinburgh
Novel transcriptional domains which are susceptibility markers for disease?

S

Dr J K P Sheehan
Department of Biochemistry and Molecular Biology, University of Manchester
Creating models for studying the basis for self and non-self recognition at the cellular level

Professor A J Smith
School of Dentistry, University of Birmingham
New biological approaches to dental tissue repair: growth factors as key mediators of cellular and molecular processes

Professor C J Stirling
School of Biological Sciences, University of Manchester
Are small proteins a missing part of the big picture?

T

Mr P G Taylor
Department of Biology, University College London
Calibrating the modular clock: elucidation of mutation dynamics and human population history through the use of single-molecule PCR

Dr N Thomas
Department of Chemistry, University of Nottingham
'Augmented SELEX' - a method to generate and select co-enzyme dependent catalytic RNA/DNA aptamers

Dr A M Tolkovsky
Department of Biochemistry, University of Cambridge
A novel strategy for identifying target derived neurotrophic factors using cognate neurons as selective molecular sieves

U

Dr I F Uchegbu
Department of Pharmaceutical Chemistry, University of Strathclyde
In vivo testing of vesicle systems for gene delivery

V

Dr M E Viney
School of Biological Sciences, University of Bristol
The genetic basis of parasitism

W

Professor B Walker
Department of Biomedical Chemistry, School of Pharmacy, Queen's University of Belfast
The development of novel approaches for the real-time monitoring and inhibition of intracellular proteolysis in living cells

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