The age of chance
After treatment with iproniazid, patients with tuberculosis sometimes became unusually happy. Iproniazid turned out to inhibit an enzyme that breaks down serotonin and other neurotransmitters.This led to the monoamine oxidase inhibitors class of antidepressants.
Valproic acid, part of Depakote, used to treat bipolar disorder, was discovered when it was used as a solvent in trials of a possible epilepsy drug. The treated group improved - but so did those on placebo. The effect was due to the solvent not the drug.
The cancer treatment cisplatin was discovered when researchers began studying the effects of electric currents on the growth of bacteria. The bacteria grew to great size but never divided. Further studies revealed that it was not the electric field having an effect but the action of ammonium and chloride ions on the platinum electrode, forming cisplatin.
Dedicated staff were instrumental to the discovery of cyclosporin, used to prevent organ rejection. Employees at Sandoz were encouraged to collect soil samples when on holiday or trips, as part of the search for new antimicrobial agents. An unusual fungus discovered this way, Tolypocladium inflatum, produced interesting chemicals but none looked suitable for further development. Later, though, extracts were sent for a general screening programme and turned out to be very good at suppressing the immune system.
Warfarin began life as a rat poison. Its use as a blood thinner originated in a failed suicide attempt by a US army cadet.
The use of lithium as a treatment for depression arose from a study of uric acid metabolism. A water-soluble salt, lithium urate, was used, and it was the lithium rather than the urate that actually had medical benefits.
However, while luck may have provided the lead, it took insight to spot the opportunity and a great deal of work to produce usable products. As Louis Pasteur put it, "Fortune favours the prepared mind".