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Human Genome Analysis: Genetic Analysis of Multifactorial Diseases

11-17 July 2015

Wellcome Trust Genome Campus, Hinxton, Cambridge

Now closed for applications. Please email to be added to our mailing list

Course summary

An intensive, residential, computer-based course aimed at scientists actively involved in genetic analysis of multifactorial traits.


This advanced course covers statistical methods currently used to map disease susceptibility genes, with an emphasis on (but not limited to) methods that can analyse family data or a combination of families and individuals. Discussions of the latest statistical methodology are complemented by practical hands-on computer exercises using state-of-the-art software. The statistical basics behind each method will be carefully explained so that participants with a non-statistical background can understand.

With a focus on family data, we will discuss fundamental issues needed to increase success in gene mapping studies including: optimal study design, power to detect linkage and association, determining the most appropriate statistical methods and software, interpretation of statistical results and trouble shooting. We will also cover the basic principles of statistical inference, hypothesis testing, population and quantitative genetics and Mendelian inheritance. Our interactive and intensive educational program will enable one to better carry out sophisticated statistical analyses of genetic data, and will also improve one's interpretation and understanding of the results. All the software used is freely available, so that skills learned can be easily applied after the course.

Teaching will take the form of lectures by invited speakers, informal tutorials, hands-on computer sessions, and analysis of disease family data sets. There will also be an opportunity to discuss participants' own data sets.

For more information on course content, please refer to the 2014 timetable (pdf).

Course organiser

Daniel Weeks (University of Pittsburgh, USA)

Course instructors

Heather Cordell (Institute of Genetic Medicine, Newcastle University, UK)
Janet Sinsheimer (University of California, Los Angeles, USA)
Eric Sobel (University of California, Los Angeles, USA)
Joe Terwilliger (Columbia University, New York, USA)
Simon Heath (Centre Nacional d’Anàlisi Genòmica (CNAG), Barcelona, Spain)

2015 Guest speakers

Professor Mark Caulfield (William Harvey Research Institute, UK)
Professor Eleftheria Zeggini (Wellcome Trust Sanger Institute)
Professor Eric Moses (The University of Western Australia)
Professor Michael Krawczak (Christian-Albrechts-University Kiel, Germany)
Professor Xihong Lin (Harvard School of Public Health, USA)

Feedback from the 2014 course

“I want to thank all the organizers and the instructors for having me in the course, patiently answered my questions and gave me valuable advice on my own projects.”

“Thanks for the experience and for the top level of the course. As I wrote in the previous slide, Wellcome Trust Courses are always much better than any other course I could find.”

“The course materials and tutorials are an amazing resource, and they will come in handy when trying to understand how to analyse my own data”

“Fantastic acomodation, food, and staff. Being residential meant that the instructors were approachable at all times and faciliated a friendly and interactive atmosphere.”

How to apply

The target audience is ideally postdoctoral researchers and advanced graduate students who have real data to analyse. Applications from senior established investigators are usually not considered. We aim to accept the member of a research group who is most likely to actually be analysing the data and who is most likely to share their training with other members. This course is aimed at the non-statistically trained researcher rather than those with advanced training in statistics.

The course tuition fees are subsidised by the Wellcome Trust for scientists based in non-commercial institutions anywhere in the world. This is a residential course and there is a registration fee of £935 towards board and lodging for non-commercial applicants. The fee for commercial applicants is £3150.

Limited bursaries are available for non-commercial applicants (up to 50% of fee) and are subject to open competition. If you would like to apply for a bursary, please complete the bursary section of the online application form (see below for application process).

Now closed for applications. Please email to be added to our mailing list

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